Novel Approaches in the Treatment of Vertebral Column Disorders in Small Animals

Document Type : Review article

Authors
Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Abstract
Background: Vertebral column disorders represent prevalent clinical challenges in small animals (particularly dogs and cats), significantly impacting mobility and quality of life, thus requiring effective and occasionally urgent clinical management. This article is a review article.
Objectives:
To review modern methods in the diagnosis and treatment of vertebral column disorders in small animals.
Methods: In this review, modern diagnostic and therapeutic methods were gathered and analyzed based on published evidence and studies.
Results: Traditional surgical techniques such as laminectomy and hemilaminectomy, while effective in reducing neurological symptoms, are associated with significant disadvantages including extensive soft tissue invasion, risk of infection, bleeding, secondary nerve damage, long recovery periods, and high costs. Modern diagnostic advances such as CT imaging (with high accuracy in bone injuries) and MRI (superior in evaluating soft tissues and spinal cord) enable more accurate assessment and targeted treatment planning for spinal problems. In the field of treatment, minimally invasive spine surgery using small incisions and endoscopic instruments provides advantages including reduced tissue damage, less bleeding, limited post-operative pain, and shorter convalescence. Three-dimensional printing technology increases the accuracy of prosthesis placement, and artificial disc replacement as an alternative to traditional fusion, while preserving segmental movement and preventing degeneration of adjacent vertebrae, creates better functional outcomes in predisposed breeds. Regenerative therapies such as stem cell use and platelet-rich plasma, along with complementary methods like physiotherapy and ozone therapy, form a more comprehensive approach.
Conclusions: Modern methods provide more effective and less invasive treatment options. However, challenges including high equipment costs, need for specialized training, and the necessity of protocol standardization require future attention.

Keywords

Subjects


1.       Salci H, Acar H, Taskapilioglu MO. Electromyographic evaluation of early stage results of exoscopic microdecompressive spinal surgery in dogs. Acta Scientiae Veterinariae. 2020;48. DOI: https://doi.org/10.22456/1679-9216.101278
2.       Ricciardi M, Campanella A, Grieco G, Zammit R. Usefulness of spinal unenhanced computed tomography and CT-myelography in the age of multidetector CT technology and magnetic resonance imaging-Preliminary considerations. Open Veterinary Journal. 2018;8(3):265-81. DOI: http://dx.doi.org/10.4314/ovj.v8i3.6
3.       Moore SA, Early PJ, Hettlich BF. Practice patterns in the management of acute intervertebral disc herniation in dogs. Journal of Small Animal Practice. 2016;57(8):409-15. DOI: https://doi.org/10.1111/jsap.12496
4.       Brock GW, Adeodato AG, Corrêa CG, Santana TA, Fernandes MEdSL, Coelho CMM. Prevalence and clinical features of neurological disorders in dogs attended at Federal Rural University of Rio de Janeiro (2017-2018). Acta Veterinária Brasilica. 2022;16(1). DOI: https://doi.org/10.21708/avb.2022.16.1.10348
5.       Alshami AM. Prevalence of spinal disorders and their relationships with age and gender. Saudi medical journal. 2015;36(6):725. DOI: https://doi.org/10.15537/smj.2015.6.11095
6.       Ricciardi M. Usefulness of multidetector computed tomography in the evaluation of spinal neuro-musculoskeletal injuries. Veterinary and Comparative Orthopaedics and Traumatology. 2016;29(01):1-13. DOI: 10.3415/VCOT-15-05-0082
7.       Hecht S, Cushing AC, Williams-Hagler DA, Craig LE, Thomas WB, Anderson KM, et al. Magnetic resonance imaging in 50 captive non-domestic felids-Technique and imaging diagnoses. Frontiers in Veterinary Science. 2022;9:827870. DOI: https://doi.org/10.3389/fvets.2022.827870
8.       Levent AE, Tanaka M, Kumawat C, Heng C, Nikolaos S, Latka K, et al. Diagnostic Paradigm Shift in Spine Surgery. Diagnostics. 2025;15(5):594. DOI: https://doi.org/10.3390/diagnostics15050594
9.       Park S-M, Kim H-J, Yeom JS. Is minimally invasive surgery a game changer in spinal surgery? Asian Spine Journal. 2024;18(5):743. DOI: https://doi.org/10.31616/asj.2024.0337
10.   Sabapathy V, Tharion G, Kumar S. Cell therapy augments functional recovery subsequent to spinal cord injury under experimental conditions. Stem Cells International. 2015;2015(1):132172. DOI: https://doi.org/10.1155/2015/132172
11.   Taylor JA, Bussières A. Diagnostic imaging for spinal disorders in the elderly: a narrative review. Chiropractic & manual therapies. 2012;20:1-19. DOI: https://doi.org/10.1186/2045-709X-20-16
12.   Tender GC, Davidson C, Shields J, Robichaux J, Park J, Crutcher CL, et al. Primary pain generator identification by CT-SPECT in patients with degenerative spinal disease. Neurosurgical Focus. 2019;47(6):E18. DOI: https://doi.org/10.3171/2019.9.FOCUS19608
13.   Verma M, Sood S, Singh B, Thakur M, Sharma S. Dynamic contrast-enhanced magnetic resonance perfusion volumetrics can differentiate tuberculosis of the spine and vertebral malignancy. Acta Radiologica. 2022;63(11):1504-12. DOI: https://doi.org/10.1177/02841851211043838
14.   Vedantam A, Jirjis MB, Schmit BD, Wang MC, Ulmer JL, Kurpad SN. Diffusion tensor imaging of the spinal cord: insights from animal and human studies. Neurosurgery. 2014;74(1):1-8. DOI: 10.1227/NEU.0000000000000171
15.   Weber G, Morton J, Keates H. Postoperative pain and perioperative analgesic administration in dogs: practices, attitudes and beliefs of Queensland veterinarians. Australian Veterinary Journal. 2012;90(5):186-93. DOI: https://doi.org/10.1111/j.1751-0813.2012.00901.x
16.   Hammad A, Wirries A, Ardeshiri A, Nikiforov O, Geiger F. Open versus minimally invasive TLIF: literature review and meta-analysis. Journal of orthopaedic surgery and research. 2019;14:1-21. DOI: https://doi.org/10.1186/s13018-019-1266-y
17.   Hyun S-J, Lee BH, Park J-H, Kim K-J, Jahng T-A, Kim H-J. Proximal junctional kyphosis and proximal junctional failure following adult spinal deformity surgery. Korean Journal of Spine. 2017;14(4):126. DOI: https://doi.org/10.14245/kjs.2017.14.4.126
18.   Kang T, Park SY, Kang CH, Lee SH, Park JH, Suh SW. Is biportal technique/endoscopic spinal surgery satisfactory for lumbar spinal stenosis patients?: a prospective randomized comparative study. Medicine. 2019;98(18):e15451. DOI: http://dx.doi.org/10.1097/MD.0000000000015451
19.   Itamoto K, Itoh H, Sunahara H, Horikirizono H, Nemoto Y, Tani K, et al. Comparison of surgical invasiveness between micro-endoscopic discectomy/microscopic discectomy and conventional hemilaminectomy in dogs. Journal of Veterinary Medical Science. 2023;85(6):617-24. DOI : https://doi.org/10.1292/jvms.22-0226
20.   Gong Y, Fu G, Li B, Li Y, Yang X. Comparison of the effects of minimally invasive percutaneous pedicle screws osteosynthesis and open surgery on repairing the pain, inflammation and recovery of thoracolumbar vertebra fracture. Experimental and Therapeutic Medicine. 2017;14(5):4091-6. DOI: https://doi.org/10.3892/etm.2017.5036
21.   Kim J-E, Choi D-J, Park EJ. Risk factors and options of management for an incidental dural tear in biportal endoscopic spine surgery. Asian Spine Journal. 2020;14(6):790. DOI: https://doi.org/10.31616/asj.2019.0297
22.   Łątka K, Kołodziej W, Pawuś D, Waligóra M, Trompeta J, Klepinowski T, et al. Extremely rare complications in Uniportal spinal endoscopy: A systematic review with unique case analyses. Journal of clinical medicine. 2024;13(6):1765. DOI: https://doi.org/10.3390/jcm13061765
23.   Butler AJ, Brusko GD, Wang MY. Awake endoscopic transforaminal lumbar interbody fusion: a technical note. HSS Journal®. 2020;16(2):200-4. DOI: https://doi.org/10.1007/s11420-020-09748-6
24.   Perez‐Jimenez EE, Biedrzycki AH, Morton AJ, McCarrel TM. Three‐dimensional printed guides for screw placement in equine navicular bones. Veterinary Surgery. 2021;50(4):758-66. DOI: https://doi.org/10.1111/vsu.13616
25.   Hu X, Kenan S, Cheng M, Cai W, Huang W, Yan W. 3D-Printed patient-customized artificial vertebral body for spinal reconstruction after total en bloc spondylectomy of complex multi-level spinal tumors. International Journal of Bioprinting. 2022;8(3):576. DOI: https://doi.org/10.18063/ijb.v8i3.576
26.   Tack P, Victor J, Gemmel P, Annemans L. 3D-printing techniques in a medical setting: a systematic literature review. Biomedical engineering online. 2016;15:1-21. DOI: https://doi.org/10.1186/s12938-016-0236-4
27.   Cool J, Van Schuppen J, De Boer M, Van Royen B. Accuracy assessment of pedicle screw insertion with patient specific 3Dprinted guides through superimpose CT-analysis in thoracolumbar spinal deformity surgery. European Spine Journal. 2021;30:3216-24. DOI: https://doi.org/10.1007/s00586-021-06951-9
28.   Hamilton‐Bennett SE, Oxley B, Behr S. Accuracy of a patient‐specific 3D printed drill guide for placement of cervical transpedicular screws. Veterinary surgery. 2018;47(2):236-42. DOI: https://doi.org/10.1111/vsu.12734
29.   Fujioka T, Nakata K, Nishida H, Sugawara T, Konno N, Maeda S, et al. A novel patient‐specific drill guide template for stabilization of thoracolumbar vertebrae of dogs: cadaveric study and clinical cases. Veterinary Surgery. 2019;48(3):336-42. DOI: https://doi.org/10.1111/vsu.13140
30.   Angelini A, Trovarelli G, Berizzi A, Pala E, Breda A, Ruggieri P. Three-dimension-printed custom-made prosthetic reconstructions: from revision surgery to oncologic reconstructions. International Orthopaedics. 2019;43:123-32. DOI: https://doi.org/10.1007/s00264-018-4232-0
31.   Shao Z-X, Wang J-S, Lin Z-K, Ni W-F, Wang X-Y, Wu A-M. Improving the trajectory of transpedicular transdiscal lumbar screw fixation with a computer-assisted 3D-printed custom drill guide. PeerJ. 2017;5:e3564. DOI: https://doi.org/10.7717/peerj.3564
32.   Kosmopoulos V, McManus J, Schizas C. Consequences of patient position in the radiographic measurement of artificial disc replacement angles. European Spine Journal. 2008;17:30-5. DOI: https://doi.org/10.1007/s00586-007-0486-8
33.   Lehman Jr RA, Lenke LG. Long-segment fusion of the thoracolumbar spine in conjunction with a motion-preserving artificial disc replacement: case report and review of the literature. Spine. 2007;32(7):E240-E5. DOI: 10.1097/01.brs.0000259211.22036.2a
34.   Bao D, Li D. Anterior spinal instrumentation combining a prosthetic disc nucleus with a flexible stabilization device: Manufacture and use in intervertebral disc repair. Experimental and Therapeutic Medicine. 2018;15(3):3040-4. DOI: https://doi.org/10.3892/etm.2018.5745
35.   Cunningham BW, Gordon JD, Dmitriev AE, Hu N, McAfee PC. Biomechanical evaluation of total disc replacement arthroplasty: an in vitro human cadaveric model. Spine. 2003;28(20S):S110-S7. DOI: 10.1097/01.BRS.0000092209.27573.90
36.   Kasliwal MK, Deutsch H. Lumbar disc replacement in adolescents: An initial experience in two cases. Journal of Pediatric Neurosciences. 2012;7(2):129-32. DOI: 10.4103/1817-1745.102577
37.   Kotani Y, Abumi K, Shikinami Y, Takahata M, Kadoya K, Kadosawa T, et al. Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra—high strength bioresorbable spinal stabilization. Journal of Neurosurgery: Spine. 2004;100(4):337-42. DOI: https://doi.org/10.3171/spi.2004.100.4.0337
38.   Bajnoczy S. Artificial disc replacement—Evolutionary treatment for degenerative disc disease. AORN journal. 2005;82(2):191-206. DOI: https://doi.org/10.1016/S0001-2092(06)60311-6
39.   Hernandez J, Torres-Espin A, Navarro X. Adult stem cell transplants for spinal cord injury repair: current state in preclinical research. Current stem cell research & therapy. 2011;6(3):273-87. DOI: https://doi.org/10.2174/157488811796575323
40.   Ridlen R, Marsters V, Clarke E, McGrath K, Gorrie CA. Development of a chronic compression spinal cord injury model in neonatal and adult rats. Animal Models and Experimental Medicine. 2024;7(5):758-68. DOI: https://doi.org/10.1002/ame2.12484
41.   Chen KS, Sakowski SA, Feldman EL. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis. Annals of neurology. 2016;79(3):342-53. DOI: https://doi.org/10.1002/ana.24584
42.   Bergh A, Lund I, Boström A, Hyytiäinen H, Asplund K. A systematic review of complementary and alternative veterinary medicine:“Miscellaneous therapies”. Animals. 2021;11(12):3356. DOI: https://doi.org/10.3390/ani11123356
43.   Weiermayer P, Frass M, Peinbauer T, Ellinger L, De Beukelaer E. Evidence-Based Human Homeopathy and Veterinary Homeopathy. Comment on Bergh et al. A Systematic Review of Complementary and Alternative Veterinary Medicine:“Miscellaneous Therapies”. Animals 2021, 11, 3356. Animals. 2022;12(16):2097. DOI: https://doi.org/10.3390/ani12162097
44.   Costa R, Hassur R, Jones T, Stein A. The use of pain scales in small animal veterinary practices in the USA. Journal of small animal practice. 2023;64(4):265-9. DOI: https://doi.org/10.1111/jsap.13581
45.   Stanossek I, Wehrend A. Application of veterinary naturopathy and complementary medicine in small animal medicine—A survey among German veterinary practitioners. Plos one. 2022;17(2):e0264022. DOI: https://doi.org/10.1371/journal.pone.0264022
46.   Bocci V, Zanardi I, Travagli V. Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects. Medical gas research. 2011;1:1-9. DOI: https://doi.org/10.1186/2045-9912-1-6
47.   Orlandin JR, Machado LC, Ambrósio CE, Travagli V. Ozone and its derivatives in veterinary medicine: A careful appraisal. Veterinary and Animal Science. 2021;13:100191. DOI: https://doi.org/10.1016/j.vas.2021.100191
48.   Keyerleber MA, McEntee MC, Farrelly J, Podgorsak M. Completeness of reporting of radiation therapy planning, dose, and delivery in veterinary radiation oncology manuscripts from 2005 to 2010. Veterinary Radiology & Ultrasound. 2012;53(2):221-30. DOI: https://doi.org/10.1111/j.1740-8261.2011.01882.x
Volume 12, Issue 1 - Serial Number 23
November 2025
Pages 96-108

  • Receive Date 13 October 2025
  • Accept Date 16 October 2025
  • Publish Date 22 November 2025