List of Articles Alireza Shaikhzadeh

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  1 - patellar luxation in dogs
  Alireza Shaikhzadeh Amin Bigham-Sadegh
  20.1001.1.24235695.1402.10.1.10.8
  Patellar luxation is a common orthopedic problem in dogs. Both large and small breed dogs may be affected; the disease may be seen in cats as well. Medial luxation is more common than lateral luxation and is usually diagnosed in dogs of small breed. patellar luxation ba More

  Patellar luxation is a common orthopedic problem in dogs. Both large and small breed dogs may be affected; the disease may be seen in cats as well. Medial luxation is more common than lateral luxation and is usually diagnosed in dogs of small breed. patellar luxation based on severity of occurred changes divided to 4 different grades. Patellar luxation is a congenital/developmental disorder, but it could be secondary to traumatic accident causing tearing or stretching of the joint capsule and fascia, leading to femoropatellar instability. Diagnosis is based on clinical evidence of patellar instability; however, diagnostic imaging is required to assess the amount of skeletal deformity and then the most appropriate method of treatment. Clinical signs of dogs with patellar luxation can vary from animal to animal and are only partially related to the degree of concomitant skeletal deformities. Lameness may be intermittent or continuous, and usually is a mild-to-moderate weight bearing lameness with occasional lifting of the limb. Concurrent rupture of the CrCL has been reported in a study in 41% of the stifle joints of dogs with medial patellar luxation. Surgical options include both soft tissue and osseous techniques, however, in most of the cases, a combination of more procedures is used to achieve the correction of the luxation. Complication rate is generally low and the most common complications include reluxation and implant-associated complications. Prognosis is generally favorable, with most of the dogs returning to normal limb function. This article describes patellar luxation features in dogs, including clinical presentation, diagnosis, and treatment options available Manuscript profile
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  2 - The healing process of bone lesions and fractures, effective treatment methods
  Haniyeh yabandeh jahromi Abodol hamid Meymandi Parizi Alireza Shaikhzadeh
  20.1001.1.24235695.1402.10.1.9.7
  Fracture repair involves proliferation and differentiation of multiple tissue types in a sequence followed by regeneration. All of these processes may be affected by medications. Some drugs can affect the proliferation of primary callus tissue, others can affect the dif More

  Fracture repair involves proliferation and differentiation of multiple tissue types in a sequence followed by regeneration. All of these processes may be affected by medications. Some drugs can affect the proliferation of primary callus tissue, others can affect the differentiation of chondrocytes or osteoblasts, formation of capillaries, sensitivity to mechanical input, etc. Therefore, the subject of drugs and fracture repair not only includes pharmacology and orthopedics, but also includes a wide scope. Repair steps after bone damage include: stage 1: (swelling stage), stage 2: (primary bone repair): over the next 4 to 21 days, a callus is formed around the broken bone. In this stage, a substance called collagen gradually replaces the blood clot. Step 3: (secondary bone repair) approximately two weeks after the fracture, cells called osteoblasts start working. These cells cause new bone to fuse and provide minerals needed for bone strength. Step 4: (reconstruction step): in this stage, cells called osteoclasts make the needed changes and adjustments. These cells break down any extra bone that is formed during this healing phase to return the bone shape to its normal status. In current veterinary and also human orthopedics, bone grafts are used for stimulation of fractures healing, accelerate joint fusion and repair of bone defects. Native grafted bone in addition to healing stimulator substances, contains cells that do not stimulate immune reactions and do not transmit infectious diseases. Currently, due to the problems of autologous bone grafting, the desire to use non-autologous bone grafts such as allograft and xenograft has increased. Kinetic hydroxyapatite, tricalcium phosphate and their both combination are among the common materials for bone grafting. Hydroxyapatite works as a scaffold for the growth of bone-forming cells; tarantula cubensis is an extract that is widely used in the treatment of tumors, smallpox, septicemia and toxemic diseases. Also, other materials that are used as substitutes, after being implanted at the site of bone lesions, induce the differentiation of undifferentiated mesenchymal cells present at the site of the lesion into chondrocytes or immature bone cells, and finally, the defects are successfully repaired. Manuscript profile